Course Code: ER20-12P

75 Hours (3 Hours/week)

Scope: This course is designed to impart basic training and hands-on experiences to synthesis chemical substances used as drugs and pharmaceuticals. Also, to perform the quality control tests, impurity testing, test for purity and systematic qualitative analysis of chemical substances used as drugs and pharmaceuticals.

Course Objectives: This course will provide the hands-on experience on the following aspects of chemical substances used as drugs and pharmaceuticals

  1. Limit tests and assays of selected chemical substances as per the monograph

  2. Volumetric analysis of the chemical substances

  3. Basics of preparatory chemistry and their analysis

  4. Systematic qualitative analysis for the identification of the chemical drugs


Course Outcomes: Upon successful completion of this course, the students will be able to

  1. Perform the limit tests for various inorganic elements and report

  2. Prepare standard solutions using the principles of volumetric analysis

  3. Test the purity of the selected inorganic and organic compounds against the monograph standards

  4. Synthesize the selected chemical substances as per the standard synthetic scheme

  5. Perform qualitative tests to systematically identify the unknown chemical substances

Practicals

  1. Limit test for

Chlorides; sulphate; Iron; heavy metals

  1. Identification tests for Anions and Cations as per Indian Pharmacopoeia

  2. Fundamentals of Volumetric analysis

Preparation of standard solution and standardization of Sodium Hydroxide, Potassium Permanganate

  1. Assay of the following compounds

● Ferrous sulphate- by redox titration

● Calcium gluconate-by complexometric

● Sodium chloride-by Modified Volhard's method

● Ascorbic acid by iodometry

● Ibuprofen by alkalimetry

  1. Fundamentals of preparative organic chemistry

Determination of Melting point and boiling point of organic compounds

  1. Preparation of organic compounds

  • Benzoic acid from Benzamide

  • Picric acid from Phenol

  1. Identification and test for purity of pharmaceuticals

Aspirin, Caffeine, Paracetamol, Sulfanilamide

  1. Systematic Qualitative analysis experiments (4 substances)

Assignments

The students shall be asked to submit the written assignments on the following topics (One assignment per student per sessional period. i.e., a minimum of THREE assignments per student)

  1. Different monographs and formularies available and their major contents

  2. Significance of quality control and quality assurance in pharmaceutical industries

  3. Overview on Green Chemistry

  4. Various software programs available for computer aided drug discovery

  5. Various instrumentations used for characterization and quantification of drug